Southampton have made four changes from Saturday's 3-0 defeat against Everton ahead of their Europa League qualifying playoff first leg at home to FC Midtjylland.
Oriol Romeu is handed his first start for the Saints, while Steven Caulker, James Ward-Prowse and Jay Rodriguez are restored to the starting XI.
Sadio Mane also starts for Ronald Koeman despite recent rumours linking the striker with a move to Manchester United.
Meanwhile, there are two changes for the Danish champions as Petter Andersson and Morten Rasmussen start in place of Kristoffer Olsson and Martin Pusic.
Southampton: Stekelenburg, Caulker, Fonte, Yoshida, Targett, Wanyama, Romeu, Ward-Prowse, Mane, Rodriguez, Pelle
Subs: Davis, Cedric, Long, Davis, Tadic, Martina, Juanmi
Midtjylland: Dahlin, Romer, Hansen, Sviatchenko, Lauridsen, Sisto, Poulsen, Sparv, Royer, Andersson, Rasmussen
Subs: Pusic, Urena, Olsson, Banggaard, Jensen, Andersen, Onuachu, Hassan
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