Gary Neville has made two changes to the Valencia starting lineup for his first game in charge against Lyon.

Joao Cancelo and Shkodran Mustafi will start in defence with Aderlan Santos dropping to the bench, while Ruben Vezo misses out on a place in the matchday squad.

Former Manchester United full-back Rafael starts for Lyon while 35-year-old Steed Malbranque could come off the bench.

Alexandre Lacazette is partnered up front with Maxwel Cornet.

Valencia: Domenech, Cancelo, Mustafi, Abdennour, Gaya, Parejo, Perez, Danilo, Mina, De Paul, Alcacer
Subs: Santos, Negredo, Piatti, Martinez, Ryan, Carbonell Gil, Gil de Pareja

Lyon: Lopes; Rafael, Yanga-Mbiwa, Morel, Bedimo; Gonalons, Darder, Tolisso, Grenier; Lacazette, Cornet
Subs: Kone, Bisevac, Beauvue, Ghezzal, Malbranque, Mvuemba, Gorgelin