Claudio Ranieri starts with Giampaolo Pazzini and Diego Milito in attack as Inter Milan look to avenge their midweek Champions League exit.
A four-man midfield features Argentine duo Esteban Cambiasso and the evergreen Javier Zanetti, while Wesley Sneijder misses out through injury.
Atalanta also start with two men up front, in the form of Guido Marilungo and Alessandro Carrozza.
Inter: Julio Cesar; Walter Samuel, Lucio, Yuto Nagatomo, Maicon; Esteban Cambiasso, Andrea Poli, Joel Chukwuma Obi, Javier Zanetti; Giampaolo Pazzini, Diego Milito
Atalanta: Andrea Consigli; Thomas Manfredini, Michele Ferri, Gianpaolo Bellini, Christian Raimondi; Luca Cigarini, Carlos Carmona, Maximiliano Moralez, Matias Schelotto; Guido Marilungo, Alessandro Carrozza
