England head coach Eddie Jones has named four uncapped players in his 34-man squad for the Autumn internationals.
Raffi Quirke, Tommy Freeman, Mark Atkinson and Nic Dolly have all been included by Jones for the games with Tonga, Australia and South Africa.
Among the high-profile absentees are Mako and Billy Vunipola, while Jamie George and George Ford would have also expected to have earned selection.
Speaking upon announcing the squad, Jones said: "This is a young but very good, talented squad who have all earned their places. It is one of the most competitive squads I have ever picked."
The first of the three games takes place at Twickenham on November 6, with the following fixtures being staged on November 13 and November 20 respectively.
England's squad in full: Jamie Blamire, Callum Chick, Luke Cowan-Dickie, Tom Curry, Trevor Davison, Nic Dolly, Alex Dombrandt, Charlie Ewels, Ellis Genge, Jonny Hill, Maro Itoje, Courtney Lawes, Lewis Ludlam, Joe Marler, George Martin, Sam Simmonds, Kyle Sinckler, Will Stuart, Sam Underhill, Mark Atkinson, Owen Farrell, Tommy Freeman, George Furbank, Max Malins, Jonny May, Raffi Quirke, Adam Radwan, Harry Randall, Henry Slade, Marcus Smith, Freddie Steward, Manu Tuilagi, Anthony Watson, Ben Youngs
