Roma vs. Bologna (Monday, 5.30pm)
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On track for another European final and in contention for a return to the Champions League, in-form Roma welcome top-five rivals Bologna to Stadio Olimpico on Monday.
Ahead of a crucial clash between two teams vying for a seat at Europe's top table, the hosts have recorded three big wins on the spin, while their visitors have proven one of the toughest sides to beat throughout Serie A.
We say: Roma 1-0 Bologna
Roma have had less chance to rest and recover, but they have recently shown an ability to grind out results rather than simply playing on the front foot under Daniele De Rossi. Bologna (seven) are one of only two teams to have scored more goals in second-half stoppage time than the Giallorossi (five) in Serie A this season, so this contest could go right to the wire.
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AC Milan vs. Inter Milan (Monday, 7.45pm)
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Italy's top two go toe to toe in Monday's Derby della Madonnina, as Inter Milan try to claim the Scudetto at the expense of city rivals AC Milan.
The Serie A giants will convene at San Siro for a high-stakes Milan derby, with Inter aiming to secure the title against their old foes for the first time in history.
We say: AC Milan 1-2 Inter Milan
A significant moment in the 114-year history of the Milan clubs' rivalry is in prospect on Monday evening, when the chance to secure an unforgettable Scudetto should drive Inter on to beat the old enemy for a sixth straight time.
While tough to take for the Rossoneri, that would prove fitting reward for the Nerazzurri's superb Serie A season.