Fulham can strengthen their grasp on a top-ten place in the Premier League table by taking three points at home to Chelsea.
However, the Cottagers have not beaten their West London neighbours in their last 12 attempts.
Meanwhile, Chelsea will be looking to turn up the heat on Tottenham Hotspur, who face Norwich City earlier in the day.
If Spurs lose, Chelsea can climb into the Champions League places with a victory.
Martin Jol will be without Bryan Ruiz after the Costa Rican suffered a suspected broken foot during the 3-0 win at Bolton Wanderers.
Captain Danny Murphy could return after illness while Pavel Pogrebnyak will face a late fitness test.
Steve Sidwell, Zdenek Grygera, Andrew Johnson and Eddie Johnson are all ruled out.
Roberto Di Matteo still has doubts over the fitness of John Terry, Frank Lampard, Ashley Cole and Ramires, after the quartet missed the 2-1 win over Wigan Athletic.
Current form
Fulham: WLLLWW
Chelsea: LDWWWW
Possible lineups:
Fulham: Schwarzer; Kelly, Hughes, Hangeland, Riise; Duff, Dembele, Diarra, Murphy, Dempsey; Pogrebnyak
Chelsea: Cech; Ivanovic, Luiz, Terry, Bertrand; Essien, Lampard, Ramires; Torres, Mata, Drogba
Sports Mole says: 1-2
