Everton vs. Liverpool (Saturday, 12.30pm)
© Imago
Goodison Park will host the 245th Merseyside derby between Everton and Liverpool in the Premier League on Saturday.
This fixture will be a poignant occasion, given that it will be the final derby played at Goodison before Everton move to their new stadium on Bramley-Moore Dock next season.
We say: Everton 0-2 Liverpool
Everton's huge win in midweek will make the pre-match atmosphere more positive and optimistic, but their record against Liverpool speaks for itself, with just six wins in 54.
Even when Liverpool were not the well-oiled machine they are now, they would still often get the better of the neighbours, and despite a minor blip on Wednesday, they are still clear favourites for good reason here.
> Click here to read our full preview for this match
> Who will make way for Alexander-Arnold, Diaz? Liverpool predicted XI vs. Everton
> Could Broja be the only change? Everton predicted lineup vs. Liverpool
> Alisson closing in on return: Liverpool injury list for Everton clash
Aston Villa vs. Southampton (Saturday, 3.00pm)
© Imago
Having experienced very different fortunes in midweek, Aston Villa and the Premier League's rock-bottom side Southampton will clash at Villa Park on Saturday.
While Villa finally ended their winless streak at the expense of Brentford, the Saints suffered a home hammering by Chelsea and are firmly rooted in the relegation zone.
We say: Aston Villa 2-0 Southampton
Looking less like a pale shadow of their former selves, Aston Villa seemed more vibrant in midweek, so they can kick on and secure back-to-back wins in the Premier League.
Southampton's string of absences have only served to increase their misery, and they are set to return south empty-handed.
> Click here to read our full preview for this match
> Emery to tinker with winning team? Predicted Aston Villa lineup vs. Southampton
> Who steps in for Stephens? Predicted Southampton lineup vs. Aston Villa
Brentford vs. Newcastle (Saturday, 3.00pm)
© Imago
Locked together on 20 points in the Premier League standings, mid-table battlers Brentford and Newcastle United face off at the Gtech Community Stadium on Saturday afternoon.
The Bees made an unsuccessful jaunt to Aston Villa in midweek, losing 3-1 to Unai Emery's side, while the Magpies played out a sensational six-goal stalemate with leaders Liverpool.
We say: Brentford 2-2 Newcastle United
No sheets should be clean at a ground renowned for absorbing affairs, but while Brentford have been finding the net for fun on home soil all season long, their defending still leaves more questions than answers.
Also coming up against a Newcastle side who have been their Premier League kryptonite for the past three years, the Bees may have to settle for just the one point at the conclusion of another multiple-goal classic.
> Click here to read our full preview for this match
> Three changes from Howe? Predicted Newcastle XI against Brentford
> Midfield doubts, will Thiago start? Predicted Brentford XI against Newcastle
Crystal Palace vs. Man City (Saturday, 3.00pm)
© Imago
Seeking to win back-to-back Premier League matches in the space of just four days, Manchester City travel to Selhurst Park to take on Crystal Palace on Saturday afternoon.
The Eagles picked up a point in a 2-2 draw at the Etihad Stadium this time last year, before losing 4-2 to the Citizens on home soil in April.
We say: Crystal Palace 1-2 Manchester City
Man City may have kept a clean sheet in midweek, but they still look vulnerable at the back and Crystal Palace will fancy their chances of making the net ripple, as they have scored multiple goals on six occasions against Guardiola's side since his arrival at the club in 2016 - only Tottenham (nine) have done so on more occasions in that period.
However, if the Citizens can reproduce their confident display from midweek and have the likes of De Bruyne pulling the strings from midfield, we can see the visitors coming away from Selhurst Park with maximum points.
> Click here to read our full preview for this match
> Defensive dilemma: Predicted Man City lineup vs. Crystal Palace
> Kamada, Doucoure decisions to be made: Predicted Crystal Palace lineup vs. Man City
> Ake, Akanji, Foden, Stones latest: Man City injury list for Crystal Palace clash
Man Utd vs. Nott'm Forest (Saturday, 5.30pm)
© Imago
Manchester United and Nottingham Forest will endeavour to bounce back from midweek Premier League defeats when they lock horns at Old Trafford on Saturday evening.
The two teams meet for the first time since February when the Red Devils claimed a narrow 1-0 victory at the City Ground in the FA Cup fifth round, courtesy of a late header from Casemiro.
We say: Manchester United 2-0 Nottingham Forest
Both teams will be keen to make a swift return to winning ways following their midweek losses, particularly Man United on home soil as they can ill-afford to fall further behind in the race for the top four.
Forest have the attackers at their disposal to cause Man United problems on the counter-attack, but the Red Devils have impressed on home soil in recent weeks and should find a way to come out on top, potentially keeping a clean sheet in the process.
> Click here to read our full preview for this match
> Elanga to face former club? Predicted Nott'm Forest lineup vs. Man United
> Martinez, Mainoo set to return: Predicted Man United lineup vs. Nott'm Forest
> Shaw update and a double boost: Man United injury, suspension news vs. Forest
Find out more about upcoming fixtures, odds and offers in our guide to Premier League betting sites.