Huesca vs. Atletico (Wednesday, 6.00pm)
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Atletico Madrid make the trip to La Liga minnows Huesca on Wednesday evening looking to build on their dominant 6-1 victory over Granada at the weekend.
Meanwhile, newly-promoted Huesca head into their clash with last season's Champions League quarter-finalists having already recorded draws away at Villarreal and Valencia.
We say: Huesca 0-4 Atletico Madrid
While Huesca deserve credit for their start to the season, this match may prove to be one step too far. Atletico were in ruthless mood against Granada, and we expect more of the same on Wednesday evening.
Our tipster partners are predicting a double chance bet on a home win or an away win.
> Click here to read our full preview for this match
Villarreal vs. Alaves (Wednesday, 6.00pm)
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Villarreal welcome Alaves to Estadio de la Ceramica on Wednesday evening looking to bounce back from their 4-0 defeat at Barcelona.
Meanwhile, Alaves head into the contest having only recorded one point from their opening three matches in La Liga this season.
We say: Villarreal 2-1 Alaves
With Villarreal's confidence potentially being knocked by the setback at Camp Nou, this game could be closer than many are predicting. Nevertheless, the home side's extra quality should shine through against opponents who would be delighted if they were able to earn a share of the spoils.
Our tipster partners are predicting over 1.5 goals.
> Click here to read our full preview for this match
Real Madrid vs. Real Valladolid (Wednesday, 8.30pm)
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La Liga champions Real Madrid are in home action for the first time this season on Wednesday evening as they take on Real Valladolid.
Los Blancos have collected four points from their opening two matches, both on their travels, while Valladolid are winless in their three matches so far.
We say: Real Madrid 3-0 Real Valladolid
Madrid have not quite clicked into gear yet but they enter this first home fixture of the campaign as strong favourites. Valladolid tend to struggle on their travels and we are going with a routine victory for the champions on Wednesday.
Our tipster partners are predicting a home win.
> Click here to read our full preview for this match
> How Real Madrid could line up against Real Valladolid
> Real Madrid injury, suspension list vs. Valladolid
Eibar vs. Elche (Wednesday, 8.30pm)
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Eibar and Elche will both be looking to get off the mark with their first La Liga victory of the campaign when they meet at Ipurua Municipal Stadium on Wednesday evening.
The hosts have collected one point from their first three matches and are in the bottom three, as are recently-promoted Elche after losing 3-0 in their only game so far.
We say: Eibar 1-0 Elche
Eibar need to get points on the board following a disappointing start to their campaign, and this fixture presents them with a great chance to do exactly that.
Elche were beaten heavily in their first game back at this level and will need to quickly learn lessons if they are to climb off the foot of the division, but we are going with a home win on Wednesday.
Our tipster partners are predicting a double chance bet on a home win or draw.