Bayern vs. VfL Bochum (Saturday, 2.30pm)
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Bayern Munich will be aiming to remain top of the Bundesliga when they host VfL Bochum on Saturday.
The visitors, meanwhile, moved outside of the bottom three by winning a fifth successive home match last weekend.
We say: Bayern Munich 3-0 VfL Bochum
Although Bochum have undoubtedly hugely improved under Letsch's management, their away form has remained poor. Bayern should be confident of earning a comfortable victory here.
Nagelsmann will be keen for his players to secure an early healthy lead, with the 35-year-old likely to have one eye on taking their foot off the gas ahead of his side's forthcoming European tie against PSG on Tuesday.
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Freiburg vs. Stuttgart (Saturday, 2.30pm)
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Local rivals Freiburg and Stuttgart will be leaving it all out on the pitch at Europa-Park Stadion when they meet in the Bundesliga on Saturday.
Freiburg would move into the Champions League places with a victory, while Stuttgart require all three points to move outside of the bottom three.
We say: Freiburg 2-0 Stuttgart
Although Freiburg are yet to find their top form since returning to action after the World Cup, it is surely only a matter of time until Streich's side put together the sort of winning run we have seen so often from them in recent times.
Stuttgart, on the other hand, appear to be in a significant spot of bother having only won three league games so far this season. They are likely to fall to a third successive defeat on Saturday.
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Mainz vs. Augsburg (Saturday, 2.30pm)
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Mainz 05 and Augsburg are separated by just two points in the Bundesliga table ahead of their clash at the MEWA Arena on Saturday afternoon.
Hovering just outside the bottom three, both sides will be hungry to pick up a positive result and steer clear of the relegation battle.
We say: Mainz 05 1-1 Augsburg
While Mainz have struggled on home soil this season, Augsburg have found life difficult on the road of late, meaning that Saturday's clash is likely to be a relatively cagey affair.
Given that Mainz and Augsburg find themselves just a handful of points outside the drop zone, both sides will be happy to settle for a draw, preventing a relegation rival from winning in the process.
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Hoffenheim vs. B. Leverkusen (Saturday, 2.30pm)
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Following the sacking of Andre Breitenreiter, Hoffenheim will begin life under new manager Pellegrino Matarazzo when they host Bayer Leverkusen on Saturday.
Hoffenheim find themselves just three points clear of the bottom three in the Bundesliga table, while Leverkusen sit five points above the Baden-Wurttemberg outfit.
We say: Hoffenheim 2-2 Bayer Leverkusen
Buoyed by the arrival of a new manager, the Hoffenheim players are bound to up their game in order to impress Matarazzo, but they could struggle to claim all three points on Saturday.
Although Bayer Leverkusen have lost each of their last two Bundesliga matches, they have won five of their previous seven, meaning that they will confident of avoiding defeat at the PreZero Arena.
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Werder Bremen vs. Dortmund (Saturday, 2.30pm)
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Borussia Dortmund will be aiming to extend their 100% record since returning from the World Cup when they face Werder Bremen on Saturday.
Werder, meanwhile, have won back-to-back matches to put further ground between themselves and the relegation zone.
We say: Werder Bremen 2-3 Borussia Dortmund
Only Schalke and Bochum have conceded more goals than Werder so far this season, but there is little doubt that Werner's side possess a potent threat in attack.
As such, we can envisage a highly-entertaining encounter at Weserstadion, with Dortmund potentially coming out on top to win their fifth consecutive league game.
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RB Leipzig vs. Union Berlin (Saturday, 5.30pm)
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Union Berlin will be aiming to win their fifth successive league match when they travel to RB Leipzig for the Bundesliga's Saturday night match.
Leipzig, who would consider their forthcoming opponents a major top four rival this season, will hope to return to winning ways after drawing against FC Koln last time out.
We say: RB Leipzig 1-1 Union Berlin
Both teams have amassed impressive unbeaten runs in recent weeks, and there is unlikely to be much splitting the two teams on Saturday, especially with Leipzig missing Olmo and Nkunku through injury.
As such, given the amount at stake in terms of their pursuits to finish in the top four, we can envisage both teams settling for a point should the match be heading in that direction.