Lazio host Fenerbahce in the second leg of the Europe League quarter-final looking to overturn the 2-0 deficit from Turkey.
In Serie A, Lazio are pushing for fourth but have suffered a dip in form since breezing past Stuttgart in the last 16 of the Europa League.
They have just one win from five league games and were pegged back from 1-0 up to draw 1-1 in Monday night's Rome derby.
The Turkish side are just four points behind Galatasaray in the Turkish Super League and have won four in a row since knocking out Viktoria Plzen in the last round of Europe.
For Lazio, Ederson looks likely to miss out with injury and Giuseppe Biava's red card in the Rome derby could see him lose his place, although he is likely to start.
Fenerbahce could line up with a similar XI to the one that performed so well against Lazio last week with Dirk Kuyt and Pierre Webo likely to continue up top.
Recent form
Lazio: LWLWLD
Fenerbahce: WDWWWW
Possible starting lineups
Lazio: Marchetti; Biava, Radu, Cana, Gonzales; Candreva, Onazi, Lulic, Hernanes; Ledesma, Klose
Fenerbahce: Demirel; Kormaz, Irtegun, Ziegler; Meireles, Baroni, Topuz, Erkin; Sow, Kuyt, Webo
Sports Mole says: 3-1
Matt Domm
