Manchester United have been dealt a fresh concern over the fitness of Casemiro ahead of Saturday's Premier League lunchtime kickoff against Fulham at Craven Cottage.

The Brazilian midfielder returned to the first XI against Newcastle United in the EFL Cup following an ankle issue, but Erik ten Hag was then forced to take him off at half time in that 3-0 defeat.

Casemiro is now confirmed to be out for several weeks with his hamstring problem, while none of Luke Shaw (muscle), Amad Diallo (knee), Jadon Sancho (disciplinary), Tyrell Malacia (knee) or Lisandro Martinez (foot) will be in action either.

Raphael Varane will also need assessing after missing the midweek loss due to illness, but the Frenchman should come back in alongside Harry Maguire in front of Andre Onana, who is still keeping Altay Bayindir waiting for his debut, while Victor Lindelof is now uncertain owing to his own bug.

After being left out of the Manchester derby XI, Sergio Reguilon ought to hold his place at left-back here, while a fit-again Aaron Wan-Bissaka can challenge Diogo Dalot for his right-back berth.

Casemiro's injury should open the door for Scott McTominay and Christian Eriksen to return to the centre of the park, although Sofyan Amrabat is another option to replace the stricken Brazilian and Mason Mount.

All of Bruno Fernandes, Marcus Rashford and Rasmus Hojlund are primed to return to the Red Devils' attacking quartet, where Antony may hold his place despite another ineffective display in midweek.

Manchester United possible starting lineup: Onana; Wan-Bissaka, Varane, Maguire, Reguilon; McTominay, Eriksen; Antony, Fernandes, Rashford; Hojlund