Winless Marseille will look to get their Champions League campaign off and running when Rafael Benitez's Napoli visit the South of France on Tuesday night.
L'OM have lost their last three matches in all competitions and their chances of reaching the last 16 of Europe's elite competition will be all but over if they fail to come past Napoli in Group F.
Lucas Mendes picked up an injury in Sunday's defeat to Nice and is likely to be replaced in the centre of defence by Souleymane Diawara.
Visiting Napoli fell five points behind Roma at the top of Serie A by losing 2-0 to the Giallorossi on Friday night.
Gonzalo Higuain did not feature in the Italian capital but could make his return from injury at the Stade Velodrome.
In defence, the visitors will be without Juan Zuniga and Miguel Britos, with Pablo Armero and Paolo Cannavaro set to start in their absence.
Recent form
Marseille: LLLWWD
Napoli: LWLWDW
Possible starting lineups
Marseille: Mandanda; Fanni, N'Koulou, Diawara, Mendy; Imbula, Romao; Ayew, Valbuena, Thauvin; Gignac
Napoli: Reina; Maggio, Cannavaro, Albiol, Armero; Behrami, Inler; Callejon, Hamsik, Insigne; Higuain
Sports Mole says: 1-2
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