The PA news agency understands the FA is awaiting clarification from the government to see if the new regulations will impact on England’s final Nations League fixture.

UK residents can return from Denmark but must isolate along with all members of their household for 14 days.

The rule could have serious implications for Premier League clubs ahead of the international break.

Denmark head coach Kasper Hjulmand has called up replacements for a number of England-based stars.

The Danish Football Association (DBU) says Leicester goalkeeper Kasper Schmeichel, Everton’s Jonas Lossl, Chelsea centre-back Andreas Christensen, Southampton defender Jannick Vestergaard, Tottenham midfielder Pierre-Emile Hojbjerg and Brentford duo Henrik Dalsgaard and Mathias Jensen are currently not expected to feature for Denmark in Wednesday’s friendly with Sweden.

Swedish players could therefore also be affected by the new UK government restrictions.

Manchester United defender Victor Lindelof, Newcastle full-back Emile Krafth and Everton goalkeeper Robin Olsen are in the Sweden squad for the Brondby friendly.

“The DBU’s management has in the last few days been in dialogue with both UEFA, the English Football Association, English authorities and others,” the DBU statement read.

“As DBU has not received the necessary answers from the English Football Association, national coach Kasper Hjulmand has been forced to select a number of extra players for the test match against Sweden on Wednesday, if the English authorities do not have time to change the rules in the next few days.”

The 14-day self-isolation rule would see them miss crucial Premier League games on their return, but FIFA rules issued at the start of the pandemic allows club to withdraw players from international duty if there is a risk of coronavirus infection.

Elite competitors had been exempt from any quarantine controls because they were working in a secure environment.

But the new Denmark guidelines, which came into force on Saturday morning, prevent that as the Department of Transport said: “Unlike other travel to the UK, there will be no exemptions to this quarantine policy.”

UK transport secretary Grant Shapps wrote on Twitter: “From 4am on November 7, British nationals or residents who are returning to the UK directly or indirectly from Denmark will need to self-isolate with other members of their household until two weeks have passed since they were last in Denmark.

“The @ukhomeoffice is also announcing that from 0400, Saturday November 7, visitors arriving into the UK from Denmark will not be permitted entry into the UK.

“This means all non-British national or resident travellers who have been in or transited through Denmark in the last 14 days will be denied entry by Border Force upon arrival.

“This decision to act quickly follows on from health authorities in Denmark reporting widespread outbreaks of coronavirus in mink farms. Keeping the UK public safe remains our top priority.”