Chelsea travel to Old Trafford on Sunday afternoon looking to cement their place in the top four of the Premier League.
Having secured a place in the Europa League final on Thursday evening by overcoming Basel, Rafael Benitez's men will be hoping to move a step closer to securing Champions League football for next season.
United, who have nothing left to play for after wrapping up the Premier League title, will be looking to improve on their 1-1 draw at Arsenal last weekend.
Sir Alex Ferguson's side will also have further motivation to beat Chelsea after the Blues knocked them out of both domestic cups this season.
Ferguson may make a change to the team which started against Arsenal as Shinji Kagawa is expected to replace Nani on the left side of midfield. Ashley Young is ruled out with an ankle injury, while Nemanja Vidic and Danny Welbeck are doubtful due to injuries.
Benitez is likely to make changes to the side which beat Basel, with John Terry, Ashley Cole and Demba Ba expected to return to the starting XI.
Recent form
Man Utd: WLWDWD
Chelsea: WLWWDW
Possible starting lineups
Man Utd: De Gea; Rafael, Ferdinand, Evans, Evra; Jones, Carrick, Valencia, Rooney, Kagawa; Van Persie
Chelsea: Cech; Azpilicueta, Terry, Ivanovic, Cole; Luiz, Mikel, Mata, Oscar, Hazard; Ba
Sports Mole says: 2-1