Both Liverpool and Chelsea have made numerous changes to their starting lineups from Saturday's FA Cup final.
The home side are without captain Steven Gerrard, while Maxi Rodriguez, Jonjo Shelvey and Andy Carroll all come into the team.
Petr Cech has been replaced in goal by Ross Turnbull for visiting Chelsea, who have handed a start to Michael Essien in midfield and Florent Malouda on the wing.
Liverpool: Reina; Carragher, Agger, Skrtel, Johnson; Henderson, Maxi, Shelvey, Downing; Suarez, Carroll
Chelsea: Turnbull; Ferreira, Ivanovic, Terry, Bertrand; Essien, Romeu, Ramires; Sturridge, Torres, Malouda
