The last time these two sides met was in the Premier League two seasons ago, however both teams are now vying to move into a playoff spot in the Championship.
Blackpool manager Michael Appleton has kept his faith in striker Nathan Delfouneso after his goal in last weekend's 2-2 draw at Crystal Palace. Bob Harris is also handed a starting place.
Blackburn Rovers boss Henning Berg has opted for Jordan Rhodes and Colin Kazim-Richards to lead the line, coming off the back of the side's 4-1 thrashing at the hands of Cardiff City last time out.
The Seasiders sit two places above Rovers in 11th in the Championship table, despite being level on points.
Blackpool: Gilks, Broadfoot, Baptiste, Cathcart, Harris, Angel, Osbourne, Gomes, Ince, Delfouneso, Thomas
Subs: Halstead, Eardley, Noguera, Bruna, Taylor-Fletcher, Dicko, K Phillips
Blackburn Rovers: Kean, Henley, Dann, Givet, Martin Olsson, Vukcevic, Lowe, Etuhu, King, Kazim-Richards, Rhodes
Subs: Robinson, Hanley, Ribeiro, Pedersen, Rosado, Dunn, Rochina