Inter Milan head coach Roberto Mancini has made six changes from the side that drew 1-1 with Palermo at the weekend ahead of tonight's clash with Bologna.
Former captain Andrea Ranocchia returns to the starting XI in place of the suspended Jeison Murillo, while Juan Jesus and Davide Santon come in at full-back.
Midfielders Felipe Melo and Marcelo Brozovic replace Freddy Guarin and Gary Medel, while Adem Ljajic is preferred to Manchester City loanee Steven Jovetic up front.
Hosts Bologna make four changes from the side that beat Carpi 2-1 on Saturday for tonight's fixture, as Matteo Mancosu replaces Mattia Destro up front.
Saphir Taider comes in for Godfred Donsah in midfield, while Alex Ferrari and Luca Rossettini start in defence.
Bologna: Da Costa; Ferrari, Oikonomou, Rossettini, Masina; Diawara, Taider, Rizzo; Mounier, Mancosu, Giaccherini
Subs: Stojanovic, Sarr, Morleo, Pulgar, Crisetig, Falco, Destro, Mbaye, Acquafresca, Brienza, Gastaldello, Brighi
Inter Milan: Handanovic; Santon, Miranda, Ranocchia, Juan Jesus; Melo, Kondogbia, Brozovic; Perisic, Icardi, Ljajic
Subs: Carrizo, Berni, Palacio, Jovetic, Biabiany, Telles, Guarin, Montoya, Medel, Gnoukouri, Nagatomo, Manaj