Copa del Rey defending champions Barcelona will begin the defence of their trophy with a two-leg contest against Alaves.
The Catalans will go up against the Segunda B side in the round of 16, while rivals Real Madrid will begin their campaign with a clash against Alcoyano.
The two La Liga giants will go head to head with their respective lower league competitors in the first leg on October 31, which will be followed by the second leg on November 28.
If Barca are successful in their round-of-16 meeting they will face either Cordoba or Real Sociedad in the final eight, while Madrid will face the winners of the match between Almeria or Celta de Vigo.
Meanwhile, Atletico Madrid will have to see off Jaen before reaching the last eight of the competition, while fellow La Liga outfit Valencia will go up against Llagostera in the last 16.
Final 16 fixtures:
Alcoyano vs. Real Madrid
Llagostera vs. Valencia
Cacereno vs. Malaga
Alaves vs. Barcelona
Eibar vs. Athletic Bilbao
Jaen vs. Atletico Madrid
Melilla vs. Levante
Las Palmas/Racing vs. Rayo Vallecano
Sporting de Gijon vs. Osasuna
Almeria vs. Celta Vigo
Cordoba vs. Real Sociedad
Ponferradina vs. Getafe
Valladolid vs. Real Betis
Deportivo vs. Mallorca
Real Zaragoza vs. Granada
Sevilla vs. Espanyol
Final eight fixtures:
Las Palmas/Racing-Rayo Vallecano vs. Valladolid/RealBetis
Melilla/Levante vs. Zaragoza/Granada
Deportivo/Mallorca vs. Sevilla/Espanyol
Sporting/Osasuna vs. Llagostera/Valencia
Eibar/Athletic Bilbao vs. Cacereno/Malaga
Jaen/Atletico Madrid vs. Ponferradina/Getafe
Alaves/Barcelona vs. Cordoba/Real Sociedad
Almeria/Celta Vigo vs. Alcoyano/Real Madrid
Quarter-final fixtures:
Melilla/Levante/Zaragoza/Granada vs. Deportivo/Mallorca/Sevilla/Espanyol
Almeria/Celta Vigo/Alcoyano/Real Madrid vs. Sporting/Osasuna/Llagostera/Valencia
Jaen/Atletico Madrid/Ponferradina/Getafe vs. Las Palmas/Racing/Rayo Vallecano/Valladolid/ Real Betis
Alaves/Barcelona/Cordoba/Real Sociedad vs. Eibar/Athletic Bilbao/Cacereno/Malaga
Semi-final fixtures:
Almeria/Celta Vigo/Alcoyano/Real Madrid/Sporting/Osasuna/Llagostera/Valencia vs. Alaves/Barcelona/Cordoba/Real Sociedad/Eibar/Athletic Bilabo/Cacereno/Malaga
Jaen/Atletico Madrid/Ponferradina/Getafe/Las Palmas/Racing/Rayo Vallecano/Valladolid/Real Betis vs. Melilla/Levante/Zaragoza/Granada/Deportivo/Mallorca/Sevilla/Espanyol
