Moreirense vs. Farense (Saturday, 3.30pm)
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Two newly-promoted teams will go head-to-head on Saturday when Moreirense welcome SC Farense to Parque Joaquim de Almeida Freitas.
The hosts are currently languishing in the relegation playoff spot, while Farense head into the weekend in 10th place in the Primeira Liga table.
We say: Moreirense 2-2 SC Farense
The two sides played out a 1-1 draw in July's Taca da Liga fixture before Farense won the subsequent penalty shootout, and while the visitors will want to secure an outright victory this time around, we think that they will settle for a point after losing their opening two away league matches.
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Estoril vs. Vizela (Saturday, 3.30pm)
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Estoril Praia and Vizela will both be looking to claim their second league win of the season when they face off at the Estadio Antonio Coimbra da Mota on Saturday.
The hosts, who have three points to their name, are currently sitting in the Primeira Liga relegation zone, while Vizela are a point better off in 14th place.
We say: Estoril Praia 2-2 Vizela
Both teams have found wins hard to come by in the opening stages of the new season, and with the two sides separated by just one point, we think a close-fought contest could result in the spoils being shared.
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Casa Pia vs. Guimaraes (Saturday, 6.00pm)
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Casa Pia will attempt to extend their unbeaten run to four matches when they play host to Vitoria de Guimaraes in Saturday's Primeira Liga contest.
Guimaraes, meanwhile, are looking to return to winning ways after losing their last three matches across all competitions.
We say: Casa Pia 1-1 Vitoria de Guimaraes
Having lost just one of their five league games this season, Casa Pia have proven to be a tough team to beat, and we think they will do enough to take a point from Saturday's meeting with a Guimaraes side who are low on confidence following a three-game losing run.
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Porto vs. Gil Vicente (Saturday, 8.30pm)
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Porto will look to extend their unbeaten run in the Primeira Liga to 18 matches when they welcome Gil Vicente to Estadio do Dragao on Saturday.
The visitors, meanwhile, are hoping to pick up points on their travels for the first time this season after losing their opening two away league games.
We say: Porto 3-1 Gil Vicente
Porto may have lost to Gil Vicente in their previous meeting, but we think it is unlikely that history will repeat itself with the hosts currently enjoying a fine run of form.
After winning four of their five league games, we believe Porto will showcase their firepower to get the better of a Gil Vicente side who have suffered seven straight defeats on their travels in the Primeira Liga.