Less than a week on from their first-leg derby delight, Inter Milan aim to finish the job against city rivals AC Milan when the teams reconvene at San Siro on Tuesday.
After Inter stormed to a two-goal lead in the clubs' Champions League semi-final clash, the fifth and final Derby della Madonnina of the season decides whether it will be the Nerazzurri or Rossoneri half of Italy's second city that journeys on to next month's final.
Match preview
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Peaking at precisely the right time, after a season littered with Serie A shortcomings, Inter put one foot in the C final by battering their old foes during a whirlwind first half last Wednesday, when Edin Dzeko and Henrikh Mkhitaryan turned back the clock to give the Nerazzurri a dream start.
The ex-Roma pair both struck within 11 minutes of the first whistle, and the first Milan derby to be held in Europe's top club competition for 18 years was always going Inter's way thereafter: Simone Inzaghi's side have now beaten their Rossoneri rivals three times this season, following earlier wins in the league and Supercoppa Italiana.
Remaining resilient throughout their run to this stage - in stark contrast to a record of 11 league defeats so far this season - Inter have yet to trail at any point in the knockout phase; keeping a clean sheet in four of five games.
Now on the precipice of a sixth European Cup or Champions League final - and the club's first since 2010 - the Nerazzurri are within 90 minutes of taking their place in next month's showpiece; Manchester City or holders Real Madrid will await in Istanbul, if they can hold their nerve.
The form book suggests that should be the case, as Milan have continued dropping points domestically and now trail Inter by five in the Serie A standings, while Inzaghi's men have found top form and will kick off the second leg on the back of a seven-match winning run.
With all their experience and the recent resurgence of Romelu Lukaku aiding their cause - the Belgian striker scored twice in Saturday's 4-2 win over Sassuolo - they will surely expect to progress in front of a mostly blue-and-black crowd at the teams' shared San Siro home.
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Heightening their psychological burden ahead of the second leg, Milan have now lost their last three games against Inter without scoring a single goal.
The seven-time European champions have never before gone four in a row without finding the net against the Nerazzurri, and such a sequence simply cannot continue if they are to salvage something from the clubs' semi-final tie.
Throughout Champions League history, only one team has lost the first leg of a semi by two or more goals and then went on to go through - Liverpool's incredible comeback against Barcelona in 2019 being the only exception - but that is the task standing ahead of Stefano Pioli's side.
Milan striker Divock Origi memorably scored twice in that game, but he was once more unable to find the net on Saturday evening, as the Rossoneri's recent downturn continued with a dismal 2-0 defeat at Spezia.
The thinness of Pioli's squad was exposed again at Stadio Picco, as a much-changed side hampered by several injuries were humbled by the Serie A strugglers; leaving Milan four points adrift of the top four with just three games to play.
After deposing Inter as Italian champions last year, they recently passed the Scudetto on to Champions League quarter-final victims Napoli, and hopes of a first European title since 2007 now hang by a thread heading into another clash between two kings of Calcio.
Team News
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Having made a number of changes at the weekend - to preserve his star men for Tuesday's defining derby - Inter coach Simone Inzaghi will recall players including Lautaro Martinez, Denzel Dumfries and Andre Onana against Milan.
Due to Robin Gosens having just returned to fitness following a dislocated shoulder, Federico Dimarco was retained for the win over Sassuolo, and the wing-back has assisted five goals from open play in the Champions League this season - more than any other player.
Only Milan Skriniar will definitely miss out due to injury, though Joaquin Correa picked up a knock on Saturday and may be sidelined. In any case, the Argentinian striker must make way for Martinez, while it remains to be seen whether Inzaghi will select Edin Dzeko or Romelu Lukaku as the latter's strike partner.
Milan, meanwhile, are dealing with a potentially lengthy absence list, as Junior Messias, Rade Krunic and Ismael Bennacer - whose season has now been ended by a knee injury - all joined star man Rafael Leao in missing the trip to La Spezia.
As the Rossoneri's hopes of reaching the final could hinge on Leao's availability in midweek, he will be given every chance to recover; Alexis Saelemaekers is likely to deputise if the Portugal forward fails to pass a fitness test.
Olivier Giroud returns up front, meaning demotion to the bench for Divock Origi, while captain Davide Calabria should come in for Pierre Kalulu at right-back. To add more pace in defence, Malick Thiaw is expected to replace Simon Kjaer.
Inter Milan possible starting lineup:
Onana; Darmian, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Martinez, Dzeko
AC Milan possible starting lineup:
Maignan; Calabria, Tomori, Thiaw, Hernandez; Tonali, Pobega; Diaz, Krunic, Saelemaekers; Giroud
We say: Inter Milan 2-1 AC Milan (Inter win 4-1 on aggregate)
Full to the brim with confidence and knockout-football nous, Inter's depths of talent are also more substantial than Milan's - the first leg demonstrated that much very clearly - so the Nerazzurri are set to march past their Rossoneri rivals and into the Champions League final.
For data analysis of the most likely results, scorelines and more for this match please click here.
